Adipose tissue dysfunction and metabolic syndrome among childhood acute leukaemia survivors
| Autor: | Beliard, S., Visentin, S., Cousin, B., Gaborit, B., Abdesselam, I., Oudin, C., Nowicki, M., Auquier, P., Valero, R., Guye, M., Bernard, M., Marie-christine ALESSI, Michel, G. |
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| Přispěvatelé: | Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA), Department of Pediatric Hematology and Oncology, University of Hamburg, Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), 1Nutrition, metabolic disease, Endocrinology, Assistance Publique - Hôpitaux de Marseille (APHM), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), European Association for the Study of Diabetes (EASD). GBR., Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
syndrome métabolique
preadipocyte ectopic fat leukemia Médecine humaine et pathologie metabolic x syndrome acute tissu adipeux graisse ectopique erythroblastic erythroleucémie adipose tissue Human health and pathology résistance à l'insuline [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | 52. Annual meeting of the EAAP 52. Annual meeting of the EAAP, Sep 2016, Munich, Germany. SPRINGER, Diabetologia, 59, pp.1, 2016, Diabetologia 52. Annual meeting of the EAAP, Sep 2016, Munich, Germany. SPRINGER, 59, pp.1, 2016, Diabetologia (59)2016; 52. Annual meeting of the EAAP, Munich, DEU, 2016-09-12-2016-09-16, S299-S299 Publons |
| Popis: | Événement(s) lié(s) : - European-Association-for-the-Study-of-Diabetes (EASD) Événement(s) lié(s) : - European-Association-for-the-Study-of-Diabetes (EASD); Background and aims: Long-term survivors of childhood acute leukemia are at very high risk for cardiovascular diseases (CVD). Metabolic syndrome (MS), a major risk factor for CVD, is a common complication in this population, especially for patients who received total body irradiation (TBI). Consequences of radiation exposure on adipose tissue (AT) in human in unknown.Materials and methods: To assess impact of TBI on AT, we compared the morphological and functional characteristics of AT between long-term survivors of childhood acute leukemia (patientsfrom LEA cohort) with MS who received TBI (n=12) or not (n=12). We analyzed AT repartition byDEXA and MRI, and TG content in the liver by proton magnetic resonance spectroscopy. We performed needle-aspirated of abdominal subcutaneous AT and studied characteristics of this tissue using RT-qPCR, flow cytometry and preadipocytes’ cultures.Results: Mean age was 32 years old. Patients who received TBI had more components of MS (and components were more pronounced) than those without TBI, despite a trend for a lower body massindex and waist circumference. Hepatic triglycerides content was two time higher in TBI group. No difference was found in body composition (DEXA) and visceral and subcutaneous fat surface (IRM) between the two groups. Sub-cutaneous AT gene expression of fibrosis and lipidic fat storage wassignificantly lower in AT of TBI group. Furthermore, AT gene expression of several genes involved inpreadipocytes’ differentiation were decreased in TBI group.Conclusion: These functional abnormalities of subcutaneous AT observed in patients treated with TBI could be the cause of ectopic fat storage in the liver, increasing the risk of Insulin resistance and MS. Supported by: AORC AP-HM |
| Databáze: | OpenAIRE |
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