| Autor: |
Kaczmarz, S., Goettler, J., Sollmann, N., Petr, J., Schmitzer, L., Kufer, J., Weiss, K., Hansen, M., Mouridsen, K., Zimmer, C., Hyder, F., Preibisch, C. |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Zdroj: |
BRAIN & BRAIN PET 2022, the 30th International Symposium on Cerebral Blood Flow, Metabolism and Function, 29.05.-01.06.2022, Glasgow, UK |
| Popis: |
Background:Internal carotid-artery stenosis (ICAS)accounts for approximately 10–20% of all strokes.1While effective endovascular treatment is available bycarotid artery stenting (CAS) or carotid endarterectomy(CEA), they come with substantial risks.2Those compet-ing risks complicate treatment decisions especially inasymptomatic ICAS and create the need for improvedpostoperative outcome evaluations. Moreover, revascular-ization effects on cognitive impairments are widelyunknown.3Aim:This MRI-study evaluated endovascular treatmentefficacy in asymptomatic ICAS by clinically applicablehemodynamic imaging. We evaluated capillarytransit-time heterogeneity (CTH) and relative cerebralblood volume (rCBV) with additional visual attentiontesting.Method:16 asymptomatic unilateral high-grade ICAS-patients (age 71.4>5.8y) and 17 age-matched healthycontrols (HC,age 70.8>5.3y) underwent MRI on a 3TPhilips Ingenia twice (10.5 months mean follow-up time).White matter lesions (WML) were derived from FLAIR,4CTH and rCBV from dynamic susceptibility contrast5andtheir lateralization compared within grey matter of themiddle cerebral arterial circulation.6Cognitive testingwith inter-hemispheric sensitivity was based on thetheory of visual attention.7Results/Conclusions:Ipsilateral increases of CTH byþ21.4% (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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