Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
| Autor: | Ruiz-de-Leon, MJ, Jimenez-Sousa, MA, Moreno, S, Garcia, M, Gutierrez-Rivas, M, Leon, A, Montero-Alonso, M, Gonzalez-Garcia, J, Resino, S, Rallon, N, Benito, JM, Vallejo, A, Ratlon, N, Restrepo, C, Rodriguez, N, Cabello, A, Gorgolas, M, Briz, V, Jimenez, MA, Vazquez, MS, Fernandez, A, Garcia, P, Munoz, MA, Sanchez, J, Jimenez, JL, Sepulveda, D, Garcia, I, Consuegra, I, Arnedo, M, Plana, M, Climent, N, Garcia, F, Ruiz-Mateos, E, Dominguez, B, Tarancon, L, Rafii-Elddrissi, M, Polaino, MJ, Genebat, M, Viciana, P, Leal, M, Vidal, F, Rodriguez, E, Vilades, C, Peraire, J, Romero, J, Rodriguez, C, Vera, M, Este, J, Ballana, E, Martinez, MA, Franco, S, Nevot, M, Pernas, M, Casado, C, Lopez, C, Capa, L, Perez, M, Alcami, J, Sanjuan, R, Cuevas, JM, Delgado, R, Sierra, O |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol |
| ISSN: | 1684-1182 |
| Popis: | Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. Copyright (C) 2018, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. |
| Databáze: | OpenAIRE |
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