Recensement national histologique des tumeurs primitives du système nerveux central : résultats généraux sur 40 000 cas, principales applications actuelles et perspectives. [French brain tumor database: general results on 40,000 cases, main current applications and future prospects]

Autor: Zouaoui, S., Rigau, Valérie, Mathieu-Daudé, Hélène, Darlix, A., Bessaoud, F., Fabbro-Peray, P., Bauchet, F., Kerr, C., Fabbro, M., Figarella-Branger, D., Taillandier, L., Duffau, H., Trétarre, B., Bauchet, L.
Přispěvatelé: Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service d'épidémiologie, Groupe de neuro-oncologie du Languedoc Roussillon, Service de biostatistiques, Institut Universitaire de Recherche Clinique, Service d'anatomie pathologique et de neurophatologie, Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille, Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), la Ligue nationale contre le cancer, l'Institut national du cancer, l'Associations pour la Recherche sur les tumeurs cérébrales (ARTC et ARTC Sud), les laboratoires Schering-Plough, Roche, Archimedes Pharma, Sophysa, l'ANOCE, la SFNC, le Rotary Club (AGLY), le département de l'Hérault, le groupe de neuro-oncologie du Languedoc Roussillon., Société française de neurochirurgie (SFNC) et le Club de neuro-oncologie de la SFNC, Société française de neuropathologie (SFNP), Association des neuro-oncologues d'expression française (ANOCEF), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM)
Jazyk: francouzština
Rok vydání: 2012
Předmět:
Zdroj: Neurochirurgie
Neurochirurgie, Elsevier Masson, 2012, 58 (1), pp.4-13. ⟨10.1016/j.neuchi.2012.01.004⟩
ISSN: 0028-3770
1773-0619
DOI: 10.1016/j.neuchi.2012.01.004⟩
Popis: International audience; BACKGROUND AND PURPOSE: This work aimed at prospectively record all primary central nervous system tumor (PCNST) cases in France, for which histological diagnosis was available. The objectives were to (i) create a national database and network to perform epidemiological studies, (ii) implement clinical and basic research protocols, and (iii) harmonize the health care of patients affected by PCNST. METHODS: The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase (FBTDB) (Recensement national histologique des tumeurs primitives du système nerveux central [RnhTPSNC]), and the active participation of the Scientific Societies involved in neuro-oncology in France. RESULTS: From 2004 to 2009, 43,929 cases of newly diagnosed and histologically confirmed PCNST have been recorded. Histological diagnoses included gliomas (42,4%), all other neuroepithelial tumors (4,4%), tumors of the meninges (32,3%), nerve sheath tumors (9,2%), lymphomas (3,4%) and others (8,3%). Cryopreservation was reported for 9603 PCNST specimens. Tumor resections were performed in 78% cases, while biopsies accounted for 22%. Median age at diagnosis, sex, percentage of resections and number of cryopreserved tumors were detailed for each histology, according to the WHO classification. DISCUSSION/CONCLUSION: Many current applications and perspectives for the FBTDB are illustrated in the discussion. To our knowledge, this work is the first database in Europe, dedicated to PCNST, including clinical, surgical and histological data (with also cryopreservation of the specimens), and which may have major epidemiological, clinical and research implications.
Databáze: OpenAIRE
Externí odkaz: