Pharmacogenetic profile of CYP2D6 gene in Croatian Roma
| Autor: | Stojanović Marković, Anita |
|---|---|
| Přispěvatelé: | Peričić Salihović, Marijana |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
haplotype
PRIRODNE ZNANOSTI. Biologija CYP2D6 Romske populacije Roma population haplotip udc:577(043.3) personalized medicine Biochemistry. Molecular biology. Biophysics CYP2D6 gene Roma population ADME genes pharmacogenetics personalized medicine single nucleotide polymorphism haplotype ADME genes personalizirana medicina polimorfizam jednog nukleotida single nucleotide polymorphism CYP2D6 gene Biokemija. Molekularna biologija. Biofizika geni ADME farmakogenetika NATURAL SCIENCES. Biology pharmacogenetics |
| Popis: | The CYP2D6 gene encodes the homonymous enzyme responsible for the metabolism of about 25% of clinically prescribed drugs, although it accounts for only 2% of all cytochromes in the human liver. The Roma are an example of a founder population where centuries of isolation and migrations have left their mark on the gene pool. Results of this study showed the influence of demographic history on single nucleotide polymorphisms in three socioculturally different studied Roma populations. Their South Asian origin is seen in the frequencies of polymorphic variants, as well as the increased frequency of star alleles *10 and *41. Phenotypically, normal metabolizers are the most common among Roma (51.6-65.1%), while slow metabolizers are the least common (0-7.4%). The similarity of the Roma population to European and Asian populations is evident from the LD pattern of the CYP2D6 gene region. The three Roma groups differ significantly (p |
| Databáze: | OpenAIRE |
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