| Autor: |
Xiao, Anthony Y, Wang, Jing, Saier, Milton H |
| Rok vydání: |
2010 |
| Předmět: |
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| Popis: |
Transport systems frequently include auxiliary proteins that perform subfunctions within the transporter protein complex. Two such proteins found in Gram-negative bacteria are the Membrane Fusion Proteins (MFPs) and the Outer Membrane Auxiliary (OMA) proteins. We here demonstrate that OMAs present in alpha-proteobacteria (but not in other bacterial types) contain a long alpha-helical region that is homologous to corresponding regions in the MFPs. The results suggest that during their evolution, OMAs, specifically from alpha-proteobacteria, exchanged their own alpha-helical domain for one derived from an MFP. The structural and functional implications of these findings are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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