A profile on cobas® EGFR Mutation Test v2 as companion diagnostic for first-line treatment of patients with non-small cell lung cancer

Autor:	Torres S, González Á, Cunquero Tomas AJ, Calabuig Fariñas S, Ferrero M, Mirda D, Sirera R, Jantus-Lewintre E, Camps C
Rok vydání:	2020
Předmět:	EGFR TKIs cobas® companion diagnostic mutations respiratory tract diseases
Zdroj:	EXPERT REVIEW OF MOLECULAR DIAGNOSTICS r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname
ISSN:	1473-7159
Popis:	Among non-small cell lung cancer (NSCLC) patients, there is one molecularly defined subgroup harboring activating mutations in the epidermal growth factor receptor gene ( EGFR ), which results in constitutive activation of its intrinsic kinase activity. Consistent data have demonstrated that these patients have a better outcome when treated with specific tyrosine-kinase inhibitors (EGFR-TKIs). Therefore, analysis of EGFR mutational status for treatment guidance is mandatory in this context.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3905fd072d33d555cdfa12999f977c45 https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3641 Zobrazit plný text záznamu