ortho-Lithiation Reactions of O-(3,n-Dihalophenyl) N,N-Diethylcarbamates: Synthesis of Dihalosalicylamides and 2,3,n-Trihalophenol Derivatives

Autor:	Feberero, Claudia, Velasco, Rocío, Sanz Díez, Roberto
Rok vydání:	2016
Předmět:	Chemistry Organic Química orgánica
Zdroj:	Repositorio Institucional de la Universidad de Burgos (RIUBU) instname
Popis:	New dihalosalicylamides and trihalophenol derivatives have been synthesized from easily available O-(3,n-dihalophenyl) N,N-diethylcarbamates by using a directed ortho-metalation (DoM) strategy. The o-lithiation reactions with sBuLi take place regioselectively at the doubly activated C-2 position, which demonstrates the ability of O-carbamates as directed metalating groups. In addition, highly functionalized arylnitriles were accessed from organolithium intermediates by using a tandem transnitrilation/SNAr reaction sequence. Junta de Castilla y León (Consejería de Educación) and FEDER (BU237U13 and BU076U16) as well as the Ministerio de Economía y Competitividad (MINECO) and FEDER (CTQ2013-48937-C2-1-P)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::38f64e502f2a84c055eb17316d9886e0 http://hdl.handle.net/10259/4281 Zobrazit plný text záznamu