Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma

Autor: Calcagno, Danielle Queiroz [UNIFESP], Leal, Mariana Ferreira [UNIFESP], Takeno, Sylvia Satomi [UNIFESP], Assumpcao, Paulo Pimentel de [UNIFESP], Demachki, Samia, Smith, Marilia de Arruda Cardoso [UNIFESP], Burbano, Rommel Rodríguez [UNIFESP]
Přispěvatelé: Fed Univ Para, Universidade Federal de São Paulo (UNIFESP)
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Popis: Background: Gastric cancer is the third most frequent type of neoplasia. In northern Brazil, the State of Para has a high incidence of this type of neoplasia. Limited data are available so far on the genetic events involved in this disease. Materials and Methods: Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas. Results: All cases showed aneuploidy of chromosome 8 and C-MYC amplification, in both the diffuse and the intestinal histopathological types of Lauren. No, correlation was found between polysomy 8 and the histopathological characteristics of the tumors. C-MYC amplification, like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Translocation of C-MYC was observed only in the diffuse-type. Conclusion: Chromosome 8 can be used as a marker in the diagnosis of gastric adenocarcinoma. The C-WC oncogene requires further studies in order to verify if it is, when amplified, an etiological cause of transformation or a consequence of the proliferation process. Fed Univ Para, Ctr Ciencias Biol, Dept Biol, Lab Citogenet Humana & Genet Toxicol, BR-66075900 Belem, Para, Brazil Univ Fed Sao Paulo, Dept Morphol, Discipline Genet, Sao Paulo, SP, Brazil Fed Univ Para, Joao Barros Barreto Univ Hosp, Dept Pathol, Belem, Para, Brazil Fed Univ Para, Joao Barros Barreto Univ Hosp, Surg Serv, Belem, Para, Brazil Univ Fed Sao Paulo, Dept Morphol, Discipline Genet, Sao Paulo, SP, Brazil Web of Science
Databáze: OpenAIRE
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