Syntheses, Characterization and In-Vitro Anti-Inflammatory Activity of Some Novel Thiophenes
| Autor: | Deka, Satyendra, Mohan, Shamanna, Saravanan, Janardhan, Kakati, Manoj, Talukdar, Apurba, Sahariah, Bhargab Jyoti, Dey, Biplab Kumar, Sarma, Rama Kanta |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Macedonian Journal of Medical Sciences (Archived); Vol. 5 No. 2 (2012): Jul 31 (MJMS); 159-163 Macedonian Journal of Medical Sciences; Vol 5, No 2 (2012): Jul 31 (MJMS); 159-163 Boletín epidemiológico semanal; Vol. 14 Núm. 4 (2006): Semanas 7-8; 45-46 BES. Boletín Epidemiológico Semanal instname Boletín epidemiológico semanal; Vol. 14 Núm. 4 (2006): Semanas 7-8; 41-42 |
| ISSN: | 1857-5749 1857-5773 2173-9277 1135-6286 |
| Popis: | Aim: The present study was aimed to synthesize a series of 2-substituted benzylidine imino-3-(3-chloro-4-fluorophenyl)-carboxamido-4,5-trimethylene thiophenes SPJ-1(a-m) and to evaluate their in-vitro anti-inflammatory activity.Materials and Methods: The starting material (SPJ-1) was prepared by the application of versatile Gewald reaction. The In-vitro anti-inflammatory activity of synthesized compounds [SPJ-1(a-m)] was evaluated using inhibition of bovine serum albumin denaturation method.Result: SPJ-1b and SPJ-1g have shown significant in-vitro anti-inflammatory activity.Conclusion: The findings of the present study clearly demonstrate that chloro functional group possess inhibition of bovine serum albumin denaturation capacity and has in-vitro anti-inflammatory activity. However hydroxyl, nitro, methyl, methoxy and dimethyl amino derivatives did not show any in-vitro anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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