Polymorphism of hypoxia-inducible factor-1 alpha gene in pediatric acute respiratory distress syndrome
| Autor: | Yilmaz, S, Kuskucu, A, Horoz, OO, Suakar, O, Imamova, N, Gongor, G, Yildizdas, D |
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| Přispěvatelé: | Çukurova Üniversitesi, Yilmaz, S, Kuskucu, A, Horoz, OO, Suakar, O, Imamova, N, Gongor, G, Yildizdas, D, Yeditepe Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| ISSN: | 0004-6248 |
| Popis: | WOS: 000462481900005 Objective: To examine if hypoxia-inducible factor-1 alpha (Hif-1 alpha) polymorphisms are associated with pediatric acute respiratory distress syndrome (PARDS). Methods: Twenty two patients with PARDS and 11 non-PARDS controls were examined in pediatric intensive care unit in Cukurova University Balcali Hospital. Blood polymorphism was used to assess the Hif-1 alpha C1772T and G1790A polymorphisms of Hif-1 alpha gene, and differences in genotypes between the 2 groups were compared. Results: Hif-1 alpha C1772T polymorphism was observed only in one case of PARDS group but non-PARDS group didn't show any C1772T polymorphism. Particularly, the difference in number of cases with Hif-1 alpha G1790A polymorphism was not significant between PARDS and non-PARDS groups. In addition, Hif-1 alpha G1790A polymorphism was significantly related to the distribution of lung opacities in children with PARDS (P |
| Databáze: | OpenAIRE |
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