Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment

Autor: Roos, A., Schilder-Tol, E. J. M., Weening, J. J., Jan Aten
Přispěvatelé: Other departments
Jazyk: angličtina
Rok vydání: 1998
Zdroj: Journal of leukocyte biology, 64(4), 503-510. FASEB
Scopus-Elsevier
ISSN: 0741-5400
Popis: CD134 (OX40) is involved in T cell costimulation and T cell-dependent antibody production. We show strongly increased T cell expression of CD134 in a model of T helper 2-mediated systemic autoimmunity, induced by HgCl2. Regulation of CD134 expression on CD4+ T cells was further studied in vitro, identifying CD134 as an early marker of T cell activation. CD134 expression could be induced by interleukin-4, but not by interferon-gamma or tumor necrosis factor-alpha. Effects of interleukin-4 and of phorbol 12-myristate 13-acetate on CD134 expression could be blocked by the protein kinase inhibitor staurosporin. Combination of these stimuli with ionomycin resulted in a strongly synergistic increase of CD134 expression, which was blocked by the calcineurin-inhibitor cyclosporin A. The results demonstrate the involvement of two synergistically acting pathways in induction of CD134 expression. Furthermore, they suggest a role for interleukin-4 in induction of CD134 expression in vivo
Databáze: OpenAIRE
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