Preventing unnecessary invasive cancer-diagnostic tests: Changing the cut-off points

Autor:	Pourmand, G., Ramezani, R., Sabahgoulian, B., Nadali, F., Mehrsai, A. R., Nikoobakht, M. R., Allameh, F., Hossieni, S. H., Seraji, A., Rezai, M., Fatemeh Haidari, Dehghani, S., Razmandeh, R., Pourmand, B.
Předmět:	Cut-Off Point Prostate Cancer lcsh:Public aspects of medicine PSAD lcsh:RA1-1270 TPSA PCA Diagnosis
Zdroj:	Scopus-Elsevier Iranian Journal of Public Health, Vol 41, Iss 2, Pp 47-52 (2012) Iranian Journal of Public Health, Vol 41, Iss 2 (2012)
Popis:	Background: To determine a cut-off point of tPSA and PSAD to prevent unnecessary invasive cancer-diagnosing tests in the community. Methods: This study was performed on 688 consecutive patients referred to our center due to prostatism, suspicious lesions on digital rectal examination and/or elevated serum PSA levels. All patients underwent transrectal ultrasound guided biopsies and obtained PSAD. Serum levels of tPSA and fPSA were measured by chemiluminescence. Comparisons were done using tests of accuracy (AUC-ROC). Results: Prostate cancer was detected in 334 patients, whereas the other 354 patients were suffering from benign prostate diseases. The mean tPSA in case and control groups were 28.32±63.62 ng/ml and 7.14±10.04 ng/ml; the mean f/tPSA ratios were 0.13± 0.21 and 0.26±0.24 in PCa and benign prostate disease groups; the mean PSAD rates were 0.69±2.24, 0.12±0.11, respectively. Statistically significant differences were found (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3591ba865a098aaa478415e444f69b63 http://www.scopus.com/inward/record.url?eid=2-s2.0-84875346895&partnerID=MN8TOARS Zobrazit plný text záznamu