New insights on the disease contribution of neuroinflammation in ALS
| Autor: | Chiot, Aude, Lobsiger, Christian S, Boillée, Séverine |
|---|---|
| Přispěvatelé: | Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, Hal Sorbonne Université, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lymphocytes
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology mast cells Amyotrophic Lateral Sclerosis (ALS) monocytes [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity neuroinflammation |
| Zdroj: | Current Opinion in Neurology Current Opinion in Neurology, 2019, 32 (5), pp.764-770. ⟨10.1097/WCO.0000000000000729⟩ Current Opinion in Neurology, Lippincott, Williams & Wilkins, 2019, 32 (5), pp.764-770. ⟨10.1097/WCO.0000000000000729⟩ |
| ISSN: | 1350-7540 |
| Popis: | International audience; Purpose of review: Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease with a strong neuroinflammatory component. This review summarizes how the connection between neurodegeneration and the immune system is strengthened by new discoveries from ALS genetics and the analysis of subpopulations of immune cells in ALS.Recent findings: Recent genes identified in ALS encode for proteins with direct immune roles, which when mutated lead to deregulation of immune functions, potentially influencing the disease. Although neuroinflammation in the central nervous system (CNS) of ALS patients has been well documented, new evidence suggests also direct malfunctions of immune cells in the CNS and at the periphery. Although CD4+ T-regulatory lymphocytes are protective in ALS, their number and function are altered over the disease course. CD8+ T cells are detrimental for motor neurons in the CNS but show some protective roles at the periphery. Similarly, the presence of mast cells in muscles of ALS models and patients and impairments of monocyte functions reveal potential new players in ALS disease progression.Summary: Although motor neuron degeneration is considered the prime event in ALS, dysfunctions in immune processes can impact the disease, highlighting that targeting specific immune components is a strategy for developing biomarkers and ultimately new drugs. |
| Databáze: | OpenAIRE |
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