Effect of frequent hemodialysis on residual kidney function
| Autor: | Daugirdas, John T, Greene, Tom, Rocco, Michael V, Kaysen, George A, Depner, Thomas A, Levin, Nathan W, Chertow, Glenn M, Ornt, Daniel B, Raimann, Jochen G, Larive, Brett, Kliger, Alan S, FHN Trial Group |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Time Factors Kidney Disease Clinical Trials and Supportive Activities Clinical Sciences Renal and urogenital Bioengineering Kidney Blood Urea Nitrogen Renal Dialysis Clinical Research FHN Trial Group hemodialysis hazards Humans Urea Prospective Studies Aged hemodialysis renal-function decline hemodialysis adequacy Middle Aged Urology & Nephrology United States Urodynamics Treatment Outcome Creatinine Kidney Diseases Female Biomarkers |
| Zdroj: | Kidney international, vol 83, iss 5 |
| Popis: | Frequent hemodialysis can alter volume status, blood pressure, and the concentration of osmotically active solutes, each of which might affect residual kidney function (RKF). In the Frequent Hemodialysis Network Daily and Nocturnal Trials, we examined the effects of assignment to six compared with three-times-per-week hemodialysis on follow-up RKF. In both trials, baseline RKF was inversely correlated with number of years since onset of ESRD. In the Nocturnal Trial, 63 participants had non-zero RKF at baseline (mean urine volume 0.76 liter/day, urea clearance 2.3 ml/min, and creatinine clearance 4.7 ml/min). In those assigned to frequent nocturnal dialysis, these indices were all significantly lower at month 4 and were mostly so at month 12 compared with controls. In the frequent dialysis group, urine volume had declined to zero in 52% and 67% of patients at months 4 and 12, respectively, compared with 18% and 36% in controls. In the Daily Trial, 83 patients had non-zero RKF at baseline (mean urine volume 0.43 liter/day, urea clearance 1.2 ml/min, and creatinine clearance 2.7 ml/min). Here, treatment assignment did not significantly influence follow-up levels of the measured indices, although the range in baseline RKF was narrower, potentially limiting power to detect differences. Thus, frequent nocturnal hemodialysis appears to promote a more rapid loss of RKF, the mechanism of which remains to be determined. Whether RKF also declines with frequent daily treatment could not be determined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|