| Autor: |
Durot, Eric Kanagaratnam, Lukshe Zanwar, Saurabh Kastritis, Efstathios d’Sa, Shirley Garcia-Sanz, Ramon Tomowiak, Cécile Hivert, Bénédicte Toussaint, Elise Protin, Caroline others |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Histological transformation into diffuse large B-cell lymphoma is a rare complication in patients with Waldenstrom macroglobulinemia (WM) and is usually associated with a poor prognosis. The objective of this study was to develop and validate a prognostic index for survival of patients with transformed WM. Through this multicenter, international collaborative effort, we developed a scoring system based on data from 133 patients with transformed WM who were evaluated between 1995 and 2016 (training cohort). Univariate and multivariate analyses were used to propose a prognostic index with 2-year survival after transformation as an endpoint. For external validation, a dataset of 67 patients was used to evaluate the performance of the model (validation cohort). By multivariate analysis, three adverse covariates were identified as independent predictors of 2-year survival after transformation: elevated serum lactate dehydrogenase (2 points), platelet count |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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