DNA polymerases in adaptive immunity.: DNA polymerases in adaptive immunity
| Autor: | Weill, Jean-Claude, Reynaud, Claude-Agnès |
|---|---|
| Přispěvatelé: | Reynaud, Claude-Agnès, Développement du Systeme Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Somatic Hypermutation
Immunoglobulin MESH: Humans [SDV.IMM] Life Sciences [q-bio]/Immunology repertoire diversity polymerase immunoglobulin genes MESH: B-Lymphocytes MESH: DNA-Directed DNA Polymerase MESH: Gene Conversion MESH: Immunoglobulin Class Switching [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Animals MESH: Immunity Active |
| Zdroj: | Nature Reviews Immunology Nature Reviews Immunology, 2008, 8 (4), pp.302-12. ⟨10.1038/nri2281⟩ Nature Reviews Immunology, Nature Publishing Group, 2008, 8 (4), pp.302-12. ⟨10.1038/nri2281⟩ |
| ISSN: | 1474-1741 |
| DOI: | 10.1038/nri2281⟩ |
| Popis: | review article; International audience; To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key genetic loci in each lymphoid cell. These modifications proceed through the action of lymphoid-specific proteins acting together with the general DNA-repair machinery of the cell. Strikingly, these general mechanisms are usually diverted from their normal functions, being used in rather atypical ways in order to privilege diversity over accuracy. In this Review, we focus on the contribution of a set of DNA polymerases discovered in the past decade to these unique DNA transactions. |
| Databáze: | OpenAIRE |
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