Multi-component diffusion characterization of radiation-induced white matter damage
| Autor: | Karunamuni, RA, White, NS, McDonald, CR, Connor, M, Pettersson, N, Seibert, TM, Kuperman, J, Farid, N, Moiseenko, V, Dale, AM, Hattangadi-Gluth, JA |
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| Rok vydání: | 2017 |
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| Zdroj: | Medical physics, vol 44, iss 5 Karunamuni, RA; White, NS; McDonald, CR; Connor, M; Pettersson, N; Seibert, TM; et al.(2017). Multi-component diffusion characterization of radiation-induced white matter damage. MEDICAL PHYSICS, 44(5), 1747-1754. doi: 10.1002/mp.12170. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/08r5f0zr |
| Popis: | PurposeWe used multi-b-value diffusion models to characterize microstructural white matter changes after brain radiation into fast and slow components, in order to better understand the pathophysiology of radiation-induced tissue damage.MethodsFourteen patients were included in this retrospective analysis with imaging prior to, and at 1, 4-5, and 9-10 months after radiotherapy (RT). Diffusion signal decay within brain white matter was fit to a biexponential model to separate changes within the slow and fast components. Linear mixed-effects models were used to obtain estimates of the effect of radiation dose and time on the model parameters.ResultsWe found an increase of 0.11 × 10-4 and 0.14 × 10-4 mm2 /s in the fast diffusion coefficient per unit dose-time (Gy-month) in the longitudinal and transverse directions, respectively. By contrast, the longitudinal slow diffusion coefficient decreased independently of dose, by 0.18 × 10-4 , 0.16 × 10-4 , and 0.098 × 10-4 mm2 /s at 1, 4, and 9 months post-RT, respectively.ConclusionsRadiation-induced white matter changes in the first year following RT are driven by dose-dependent increases in the fast component and dose-independent decreases in the slow component. |
| Databáze: | OpenAIRE |
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