Determinants of plasma 25-hydroxyvitamin D levels in healthy adults in the Netherlands

Autor: Grootheest, G., Milaneschi, Y., Lips, P. T. A. M., Annemieke Heijboer, Smit, J. H., Penninx, B. W. J. H.
Přispěvatelé: EMGO+ - Mental Health, Other departments, Psychiatry, Internal medicine, Clinical chemistry, EMGO - Mental health
Jazyk: angličtina
Rok vydání: 2014
Zdroj: The Netherlands Journal of Medicine, 72(10), 533-540. Van Zuiden Communications BV
Netherlands journal of medicine, 72(10), 533-540. Van Zuiden Communications BV
Scopus-Elsevier
Grootheest, G, Milaneschi, Y, Lips, P T A M, Heijboer, A C, Smit, J H & Penninx, B W J H 2014, ' Determinants of plasma 25-hydroxyvitamin D levels in healthy adults in the Netherlands ', Netherlands Journal of Medicine, vol. 72, no. 10, pp. 533-540 . < http://www.njmonline.nl/getpdf.php?id=1514 >
Grootheest, G, Milaneschi, Y, Lips, P T A M, Heijboer, A C, Smit, J H & Penninx, B W J H 2014, ' Determinants of plasma 25-hydroxyvitamin D levels in healthy adults in the Netherlands ', The Netherlands Journal of Medicine, vol. 72, no. 10, pp. 533-540 . < http://www.njmonline.nl/getpdf.php?id=1514 >
Netherlands Journal of Medicine, 72(10), 533-540. Van Zuiden Communications BV
ISSN: 0300-2977
Popis: Vitamin D plays a key role in maintaining skeletal health, but is also related to various non-skeletal health issues. Several determinants have been identified that influence blood plasma levels of 25-hydroxyvitamin D (25(OH) D), often in specific patients or elderly populations. This paper aims to replicate these findings in a healthy population. Plasma levels of 25(OH)D were measured using tandem mass spectrometry. We examined the cross-sectional association of sociodemographic, health, lifestyle and sampling characteristics with 25(OH)D in a group of 539 adults, who were healthy control subjects in the NESDA study in the Netherlands (latitude 52 °N). Mean 25(OH)D levels were 68.0 (± 27.2) nmol/l. Levels under 50 nmol/l occurred in 27% of the population; 40% reached levels above 75 nmol/l. Women had higher levels than men, and the use of oral contraceptives showed a significant positive association among females. Subjects with non-European ancestry had dramatically lower 25(OH) D levels. Other factors that were negatively associated were body mass index and the renal estimated glomerular filtration rate (eGFR). Meteorological data replaced season as a significant determinant. Moderate alcohol consumption and sports showed a positive association, while physical activity and the hepatic marker gamma-glutamyl transferase did not. Our results disconfirm the influence of age in this population of under 65 year olds. Insufficient 25(OH)D levels were common in a healthy population. The set of eight variables that were significant in a multiple regression model (sex, ancestry, oral contraceptives, eGFR, BMI, sports, alcohol, sunshine) explained 29.5% of the variance
Databáze: OpenAIRE
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