Online study partner-reported cognitive decline in the Brain Health Registry
| Autor: | Nosheny, Rachel L, Camacho, Monica R, Insel, Philip S, Flenniken, Derek, Fockler, Juliet, Truran, Diana, Finley, Shannon, Ulbricht, Aaron, Maruff, Paul, Yaffe, Kristine, Mackin, R Scott, Weiner, Michael W |
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| Rok vydání: | 2018 |
| Předmět: |
Aging
Brain Health Registry Study partner-reported outcomes Neurosciences Activities of daily living Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Cognitive decline Mild cognitive impairment Neurodegenerative Alzheimer's disease Basic Behavioral and Social Science Brain Disorders Alzheimers disease Clinical Research Behavioral and Social Science Neurological Neuropsychological tests Acquired Cognitive Impairment Dementia Mental health Cognitive neuropsychology in dementia Informant-reported outcomes Online registry |
| Zdroj: | Alzheimer's & dementia (New York, N. Y.), vol 4, iss 1 |
| Popis: | IntroductionMethods for efficiently identifying cognitive decline and Alzheimer's disease (AD) are a critical unmet need. The goal of this work was to validate novel online study partner (SP)-reported outcomes to identify cognitive decline in older adults.MethodsIn older adults enrolled in the Brain Health Registry, we analyzed associations between SP-reported cognitive decline, measured by the Everyday Cognition Scale, and either (1) participant cognition, assessed by Cogstate Brief Battery or (2) participant-reported diagnosis of mild cognitive impairment or AD.ResultsWe found strong associations between SP-reported Everyday Cognition Scale and both Cogstate scores and participant diagnosis. The associations were cognitive domain specific, dependant on participant diagnosis, and were stronger in spouse dyads and those who knew each other longer.DiscussionCollecting SP-reported data online from a large cohort is feasible. Results support the construct validity of our approach, which has the potential to facilitate clinical AD and aging research. |
| Databáze: | OpenAIRE |
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