Solar elastosis and TERT promoter mutations in cutaneous melanoma

Autor:	Johanne Lade Keller, Sakineh Yuusufi, Rikke Riber-Hansen, Torben Steiniche, Magnus Stougaard
Jazyk:	angličtina
Rok vydání:	2018
Zdroj:	Keller, J L, Yuusufi, S, Riber-Hansen, R, Steiniche, T & Stougaard, M 2018, ' Solar elastosis and TERT promoter mutations in cutaneous melanoma ', pp. 398-409 . Aarhus University
Popis:	The aims of this study were to assess the prognostic potential of solar elastosis grading and telomerase reverse transcriptase (TERT) promoter mutations (TERTpmut) in melanoma and to evaluate whether an association between solar elastosis and TERTpmut exists. Solar elastosis in the dermis was evaluated in hematoxylin and eosin-stained whole slides from 486 malignant melanomas. Pyrosequencing was used to detect TERTpmut in 189 samples. There was no association between solar elastosis and TERTpmut (P=0.3). Severe elastosis was associated with older age (P
Databáze:	OpenAIRE
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