Plasma leptin, but not adiponectin, is associated with cognitive impairment in older adults
| Autor: | Feinkohl, I., Janke, J., Slooter, A.J.C., Winterer, G., Spies, C., Pischon, T. |
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| Přispěvatelé: | Clinical sciences, Neuroprotection & Neuromodulation |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adipose Tissue/metabolism
Male Leptin/analysis Blood Glucose/metabolism Receptors Leptin/blood Plasma/chemistry Cross-Sectional Studies Cardiovascular and Metabolic Diseases Adipokines/metabolism Adiponectin/analysis Germany Cognitive Dysfunction/blood Obesity/metabolism Humans Female Receptors Adiponectin aged 80 and over hormones hormone substitutes and hormone antagonists Body mass index Aged Netherlands |
| Popis: | BACKGROUND: Leptin and adiponectin are adipose-tissue derived hormones primarily involved in glucose, lipid, and energy metabolism, inflammation, and atherosclerosis. Both adipokines may cross the blood-brain barrier but evidence on their roles in cognitive impairment is limited and conflicting. Here, we determined associations of plasma adipokine concentration with cognitive impairment in older adults. METHODS: Cross-sectional analysis of baseline data from 669 participants aged ≥65 years of the Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog) study were recruited 2014–2017 at study sites in Berlin, Germany and Utrecht, the Netherlands. Cognitive impairment was defined as the lowest tertile of a cognitive summary score derived from six neuropsychological tests. RESULTS: After adjustment for age, sex, fasting, BMI, diabetes, hypertension, cerebrovascular disease, and coronary heart disease, higher leptin concentrations and a higher leptin/adiponectin ratio (LAR) were associated with a higher odds of cognitive impairment (OR per 1 SD higher leptin concentration, 1.33; 95 % CI 1.05, 1.69; p = 0.02; OR per 1 SD higher LAR, 1.26; 95 % CI 1.01, 1.57; p = 0.04). Sensitivity analyses determined that these findings were driven by the non-obese group (BMI |
| Databáze: | OpenAIRE |
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