Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats

Autor:	Asl, S. S., Falahati, P., Riz, N. S., Molavi, N., Esmaeili, F., Azimi, Z., Sajadi, F., Hayat, P., Samzadeh-Kermani, A., mehdi mehdizadeh
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	mental disorders Apoptosis N-Methyl-3 4-Methylenedioxyamphetamine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry psychological phenomena and processes Acetylcysteine lcsh:RC321-571
Zdroj:	Basic and Clinical Neuroscience, Vol 3, Iss 1, Pp 45-48 (2011) Basic and Clinical Neuroscience, Vol 3, Iss 1, Pp 44-47 (2011) Scopus-Elsevier
ISSN:	2228-7442
Popis:	Objective(s): 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Materials and Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. Conclusion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.
Databáze:	OpenAIRE
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