Morphometric analysis of vascular clefts in children with symptoms of acute appendicitis and negative appendectomy
| Autor: | JURIĆ, BERNARDICA, STEPHANY KIRIGIN, MONICA, IVELJ, RENATO, ČIZMIĆ LELJAK, LUCIJA, PEZELJ, IVAN, ULAMEC, MONIKA, KRUŠLIN, BOŽO |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske Volume 75 Issue 2 |
| ISSN: | 1330-0164 1848-8897 |
| Popis: | Objective: Many cases of clinically suspected acute appendicitis show no microscopic signs of acute inflammation. Negative appendectomy rates differ greatly, partly due to various criteria used by different institutions to define acute appendicitis. In our practice, we have noticed that many of the negative appendectomy specimens contain prominent vascular clefts. The objective of this study was to determine the possible signifi cance of vascular clefts, which has not been investigated yet. Our hypothesis was that vascular clefts are early, as yet unrecognized signs of acute appendicitis. Methods: We conducted a retrospective study by searching for patients who had negative appendectomy at the Zagreb Children’s Hospital (2014-2019). There were 151 patients aged 1-18 years, 124 of which were included in the study group and 27 in the control group. Vascular clefts, if present, were measured microscopically. Statistical analysis was performed using Kolmogorov-Smirnov, Kruskal-Wallis, Mann Whitney, χ2 and Spearman’s rank correlation tests. The level of statistical signifi cance was set at p Cilj: Mnogi slučajevi klinički dijagnosticiranih akutnih apendicitisa ne pokazuju znakove akutne upale. Stopa negativnih apendektomija znatno varira, dijelom i zbog različitih kriterija koje razne institucije primjenjuju u defi niciji akutnog apendicitisa. U našoj svakodnevnoj praksi primijetili smo da mnogi od uzoraka negativnih apendektomija sadrže izražene vaskularne kleftove. Cilj ove studije bio je odrediti moguće značenje vaskularnih kleftova koje nitko dosad nije istražio. Naša hipoteza je bila da su vaskularni kleftovi rani, dosad neprepoznati znakovi akutnog apendicitisa. Metode: Proveli smo retrospektivnu studiju tražeći bolesnike s negativnom apendektomijom u Klinici za dječje bolesti Zagreb (2014.-2019.). Pronašli smo 151 bolesnika u dobi 1-18 godina, od kojih smo 124 uključili u istraživanu, a 27 u kontrolnu skupinu. Vaskularne kleftove smo mjerili mikroskopski. Učinjena je statistička analiza pomoću Kolmogorov-Smirnovljeva, Kruskal-Wallisova, Mann Whitneyeva, χ2 i Spearmanova rank korelacijskog testa. Razina statističke značajnosti utvrđena je na p |
| Databáze: | OpenAIRE |
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