A General Synthetic Route to Enantiopure 5-Substituted cis-Decahydroquinolines
| Autor: | Amat Tusón, Mercedes, Fabregat, Robert, Griera Farres, Rosa, Bosch Cartes, Joan |
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| Přispěvatelé: | Universitat de Barcelona |
| Předmět: | |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | A practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of 2-substituted 6-oxocyclohexenepropionates 2 with (R)-phenylglycinol, the stereoselective hydrogenation of the resulting unsaturated tricyclic lactams, and the stereoselective reductive cleavage of the oxazolidine ring. |
| Databáze: | OpenAIRE |
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