Determination of fumonisin B1 levels in body fluids and hair from piglets fed fumonisin B -contaminated diets

Autor: Souto, Pollyana C.M.C., Jager, Alessandra V., Tonin, Fernando G., Petta, Tânia, Di Gregório, Mayra C., Cossalter, Anne Marie, Pinton, Philippe, Oswald, Isabelle, Rottinghaus, George E., Oliveira, Carlos A.F.
Přispěvatelé: Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirao Preto, Department of Biosystems Engineering, School of Animal Science and Food Engineering, Plateforme Ezop (Ezop), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), Veterinary Medical Diagnostic Laboratory, University of Missouri [Columbia] (Mizzou), University of Missouri System-University of Missouri System, University of Missouri [Columbia]
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2017, 108, pp.1-9. ⟨10.1016/j.fct.2017.07.036⟩
ISSN: 0278-6915
DOI: 10.1016/j.fct.2017.07.036⟩
Popis: The levels of fumonisin B1 (FB1) residues in plasma, urine, feces and hair from 24 piglets fed FB1-contaminated diets containing 3.1, 6.1 or 9.0 μg FB1.g-1 for 28 days were determined using liquid chromatography coupled to mass spectrometry (LC-MS/MS). The levels of FB1 in plasma, urine, feces and pooled hair (n = 3) samples varied from 0.15 to 1.08 μg.L-1, 16.09-75.01 μg.L-1, 1.87-13.89 μg.g-1 and 2.08-8.09 ng.g-1, respectively. Significant correlations (r = 0.808-0.885; P < 0.001; N = 18) were found between FB1 intake and plasma FB1 on days 7, 14, 21 and 28. However, urinary FB1 correlated with FB1 intake only on days 7 and 14 (r = 0.561-572; P = 0.02; N = 18). A significant correlation (r = 0.509; P = 0.02; N = 24) was also found for the first time between FB1 in hair samples and FB1 intake. Plasma and urinary FB1 are good biomarkers of early exposure of pigs to low dietary FB1 levels, although plasma is recommended to assess prolonged exposure (>14 days). The possibility to evaluate hair as a biomarker of fumonisin exposure was established, although further studies are needed to provide physiologically based toxicokinetics of residual FB1 in the pig hair.
Databáze: OpenAIRE
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