| Autor: |
Hayes, S., Cafaro, T. A., Boguslawska, P. J., Kamma-Lorger, C. S., Boote, C., Harris, J., Young, R., Hiller, J., Nick Terrill, Meek, K. M., Serra, H. M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| ISSN: |
1090-0535 |
| Popis: |
Purpose: In the visually debilitating condition of climatic droplet keratopathy, corneal transparency is progressively lost. Although the precise cause of the disease and the mechanism by which it progresses are not known, a lifetime exposure to high solar radiation and a vitamin C–deficient diet may be involved in its development. This study examines the effect of dietary ascorbate levels and ultraviolet (UV)-B exposure on corneal stromal structure.\ud \ud Methods: Eight guinea pigs were divided into four treatment groups (A, B, C, and D). For 15 weeks, Groups A and C were fed an ascorbate-rich diet (2 mg/100 g bodyweight/day), while Groups B and D received an ascorbate-deficient diet (0.07 mg/100 g bodyweight/day). For the last 12 weeks of the study, Groups C and D also experienced chronic UVB exposure (0.12 J/cm2 for 40 min/day). Following euthanasia, the corneas were enucleated and their stromal ultrastructure examined using X-ray scattering and electron microscopy.\ud \ud Results: UVB exposure resulted in an increased corneal thickness (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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