Evaluation of a new concept of immune-enhancing diet in a model of head-injured rat with infectious complications: A proof of concept study

Autor: Breuillard, C., Cynober, L., Moinard, C.
Přispěvatelé: Université Paris Descartes - Paris 5 (UPD5), Stress Cellulaire : Physiopathologie, Stratégies Nutritionnelles et Thérapeutiques Innovantes (EA 4466), Faculté des Sciences Pharmaceutiques et Biologiques-Université Paris Descartes - Paris 5 (UPD5), Laboratoire de biologie de la nutrition (LBN), Université Paris Descartes - Faculté de Pharmacie de Paris (UPD5 Pharmacie), Université Sorbonne Paris Cité (USPC), CHU Cochin [AP-HP], Service de biochimie et de génétique moléculaire [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Nestle Clinical Nutrition (NCN), Noisiel, France., Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP]
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Clinical Nutrition
Clinical Nutrition, Elsevier, 2016, 35 (6), pp.1291-1300. ⟨10.1016/j.clnu.2016.04.018.⟩
ISSN: 0261-5614
DOI: 10.1016/j.clnu.2016.04.018.⟩
Popis: International audience; Immune-enhancing diet (IED) utilization in critically ill septic patients is still debated. A new concept of IED has been proposed combining extra glutamine sequentially with either antioxidants or other amino acids, in order to match patient requirements according to their response to injury. We evaluated whether this new IED elicits a more favorable response to stress when compared with two existing IEDs both enriched in arginine but with different levels of anti-oxidants, in a validated rat model combining head injury (HI) and infectious complications. Forty-eight HI rats were randomized into four groups (n = 11-13 per group) to receive, for 4 days, standard enteral nutrition (S), one of the two existing IEDs (IED1, IED2), or the new IED (IED3; providing glutamine and antioxidants for two days and glutamine and specific amino acids for two days). Two days after HI, the rats received an enteral bolus of luminescent Escherichia coli Xen14 to induce infection, and bacterial dissemination was evaluated. Body weight (BW) was recorded daily. Four days after HI, animals were euthanized; blood was sampled; organs were weighed; cumulated nitrogen balance (CNB) and nitrogen efficiency were determined. IED3 was more efficient than IED1 and IED2 in improving BW recovery from D3 (D3 vs. D1, p < 0.05) after HI. It significantly improved CNB and net protein utilization (IED3 vs. S, IED1, IED2, p < 0.05). An IED with sequential administration of anti-oxidants and glutamine may be better suited to meeting nutritional requirements in severe catabolic states.
Databáze: OpenAIRE
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