Effects of low intensity resistance training on nociceptive and motor response in an animal model of diffuse chronic muscle pain

Autor: Santos, André Luiz Silva
Přispěvatelé: Santana, Josimari Melo de, Melo, Vitor Ulisses de
Jazyk: portugalština
Rok vydání: 2021
Předmět:
Zdroj: Repositório Institucional da UFS
Universidade Federal de Sergipe (UFS)
instacron:UFS
Popis: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES Fibromyalgia (FM) is characterized by different factors, such as chronic musculoskeletal pain, dysregulation of cardiac autonomic control and imbalance of inflammatory biomarkers. Such conditions are associated with increased fatigue and reduced functional capacity. Pharmacotherapy is commonly recommended, especially tricyclic antidepressants, however, they can cause adverse effects such as xerostomia, sedation and tachycardia. Thus, as a nonpharmacological treatment for FM, resistance training (RT) has been widely recommended. However, the effect of this training method on the animal model that mimics FM is not yet clear in the literature. Thus, the aim of the present study was to evaluate the effects of RT on the animal model of diffuse chronic muscle pain (DCMP). For this, 24 male Wistar rats were allocated into four groups: resistance training (RT), RT control, amitriptyline (AMITRIP) and AMITRIP control, all treatment protocols lasted 4 weeks. DCMP was induced in all animals by a double injection of acidic saline (pH 4.0) into the left gastrocnemius muscle. Sensory mechanical threshold, motor activity, were evaluated before and after induction of DCMP model and, before treatment, every week and at the end. Motor coordination was assessed once a week and muscle strength of hind limbs were also evaluated every two weeks. Animals treated with either TR or AMITRIP increased the mechanical withdrawal threshold (p 0.05). However, animals with DCMP who underwent RT were able to increase the muscular strength of the hind limbs (p0,05). Porém, animais com DCMD que realizaram o TR obtiveram aumento da força muscular dos membros posteriores (p
Databáze: OpenAIRE
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