In vivo efficacy of melanoma internal radionuclide therapy with a 131I-labelled melanin-targeting heteroarylcarboxamide molecule

Autor: Degoul, F., Borel, M., Jacquemot, N., Besse, S., Communal, Y., Mishellany, F., Papon, J., Penault-Llorca, F., Donnarieix, D., Doly, M., Maigne, L., Miot-Noirault, Elisabeth, Cayre, A., Cluzel, J., Moins, N., Chezal, J.-M., Bonnet, M.
Přispěvatelé: Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Cancer
International Journal of Cancer, Wiley, 2013, 133, pp.1042-1053. ⟨10.1002/ijc.28103⟩
International Journal of Cancer, 2013, 133, pp.1042-1053. ⟨10.1002/ijc.28103⟩
ISSN: 0020-7136
1097-0215
DOI: 10.1002/ijc.28103⟩
Popis: The development of alternative therapies for melanoma treatment is of great interest as long-term tumour regression is not achieved with new targeted chemotherapies on selected patients. We previously demonstrated that radioiodinated heteroarylcarboxamide ([131I]ICF01012) induced a strong anti-tumoural effect by inhibiting both primary tumour growth and dissemination process in a B16BL6 melanoma model. In our study, we show that a single injection of [131I]ICF01012 (ranging from 14.8 to 22.2 MBq) was effective and associated with low and transient haematological toxicity. Concerning pigmented organs, cutaneous melanocytes and skin were undamaged. In 30% of treated animals, no histological alteration of retina was observed, and in the remaining 70%, damages were restricted to the optic nerve area. Using the Medical Internal Radiation Dose methodology, we determined that the absorbed dose in major organs is very low (
Databáze: OpenAIRE
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