Biomechanical Remodeling of the Diabetic Gastrointestinal Tract
| Autor: | Jingbo Zhao, Donghua Liao, Jian Yang, Hans Gregersen |
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| Přispěvatelé: | Levy , . Jerrod H. |
| Předmět: | |
| Zdroj: | Aarhus University Zhao, J, Liao, D, Yang, J & Gregersen, H 2010, Biomechanical Remodeling of the Diabetic Gastrointestinal Tract . in J H Levy (ed.), Biomechanics: Principles, Trends and Applications . Nova Publishers, USA, pp. 137-162 . |
| Popis: | Gastrointestinal tract sensory-motor abnormalities are common in patients with diabetes mellitus with symptoms arising from the whole GI tract. Common complaints include dysphasia, early satiety, reflux, constipation, abdominal pain, nausea, vomiting, and diarrhea. The pathogenesis of GI symptoms in diabetes mellitus is complex in nature, multi-factorial (motor dysfunction, autonomic neuropathy, glycemic control, psychological factors, etc.) and is not well understood. Histologically, many studies have demonstrated prominent proliferation of different GI wall layers during diabetes. During the past several years, several studies demonstrated that experimental diabetes induces GI morphological and biomechanical remodeling. Following the development of diabetes, the GI wall becomes thicker and the stiffness of the GI wall increases in a time-dependent manner. It is well known that mechanosensitive nerve endings exist in the GI tract where they serve a critical role for tissue homeostasis and symptom generation. Mechanoreceptor-like structures such as intraganglionic laminar nerve endings and intramuscular arrays have been identified. The changes of stress and strain in the GI wall will alter the biomechanical environment of the mechanosensitive nerve endings, therefore, the structure as well as the tension, stress and strain distribution in the GI wall is important for the sensory and motor function. Biomechanical remodeling of diabetic GI tract including alterations of residual strain and increase in wall stiffness will alter the tension and stress distribution in the vicinity of the mechanosensitive afferents with consequences for perception and motility of the GI tract. |
| Databáze: | OpenAIRE |
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