A pilot validation of multi-echo based echo-planar correlated spectroscopic imaging in human calf muscles
| Autor: | Furuyama, JK, Nagarajan, R, Roberts, CK, Lee, CC, Hahn, TJ, Thomas, MA |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Intracellular Fluid
Adult Male 2D correlated spectroscopy Clinical Sciences Biomedical Engineering Pilot Projects intra-myocellular and extra-myocellular lipids multi-spin echo Choline calf muscle Medicinal and Biomolecular Chemistry Bone Marrow unsaturation index Clinical Research Diabetes Mellitus Humans Muscle Cells diabetes Echo-Planar Imaging Extracellular Fluid Skeletal Middle Aged Creatine Lipids Nuclear Medicine & Medical Imaging Muscle Biomedical Imaging Multi-spin echo 2D correlated spectroscopy Type 2 |
| Zdroj: | NMR in biomedicine, vol 27, iss 10 NMR in Biomedicine, vol 27, iss 10 Furuyamaa, JK; Nagarajan, R; Roberts, CK; Lee, CC; Hahn, TJ; & Thomas, MA. (2014). A pilot validation of multi-echo based echo-planar correlated spectroscopic imaging in human calf muscles. NMR in Biomedicine, 27(10), 1176-1183. doi: 10.1002/nbm.3171. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8wm9m4xx Furuyama, JK; Nagarajan, R; Roberts, CK; Lee, CC; Hahn, TJ; & Thomas, MA. (2014). A pilot validation of multi-echo based echo-planar correlated spectroscopic imaging in human calf muscles. NMR in Biomedicine. doi: 10.1002/nbm.3171. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8359c9kj |
| Popis: | © 2014 John Wiley & Sons, Ltd. A current limitation of MR spectroscopic imaging of multiple skeletal muscles is prolonged scan duration. A significant reduction in the total scan duration using the echo-planar correlated spectroscopic imaging (EP-COSI) sequence was accomplished using two bipolar readout trains with different phase-encoded echoes for one of two spatial dimensions within a single repetition time (TR). The second bipolar readout was used for spatially encoding the outer k-space, whereas the first readout was used for the central k-space only. The performance of this novel sequence, called multi-echo based echo-planar correlated spectroscopic imaging (ME-EPCOSI), was demonstrated by localizing specific key features in calf muscles and bone marrow of 11 healthy volunteers and five subjects with type 2 diabetes (T2D). A 3 T MRI-MRS scanner equipped with a transmit-receive extremity coil was used. Localization of the ME-EPCOSI sequence was in good agreement with the earlier single-readout based EP-COSI sequence and the required scan time was reduced by a factor of two. In agreement with an earlier report using single-voxel based 2D MRS, significantly increased unsaturated pools of intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) and decreased IMCL and EMCL unsaturation indices (UIs) were observed in the soleus and tibialis anterior muscle regions of subjects with T2D compared with healthy controls. In addition, significantly decreased choline content was observed in the soleus of T2D subjects compared with healthy controls. Multi-voxel characterization of IMCL and EMCL ratios and UI in the calf muscle may be useful for the non-invasive assessment of altered lipid metabolism in the pathophysiology of T2D. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|