The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
| Autor: | O'Bryant, Sid E, Johnson, Leigh A, Barber, Robert C, Braskie, Meredith N, Christian, Bradley, Hall, James R, Hazra, Nalini, King, Kevin, Kothapalli, Deydeep, Large, Stephanie, Mason, David, Matsiyevskiy, Elizabeth, McColl, Roderick, Nandy, Rajesh, Palmer, Raymond, Petersen, Melissa, Philips, Nicole, Rissman, Robert A, Shi, Yonggang, Toga, Arthur W, Vintimilla, Raul, Vig, Rocky, Zhang, Fan, Yaffe, Kristine, HABLE Study Team |
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| Rok vydání: | 2021 |
| Předmět: |
Aging
screening and diagnosis Prevention Hispanic neurodegeneration Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) amyloid biomarkers Neurodegenerative Alzheimer's disease Brain Disorders diversity Detection mild cognitive impairment Clinical Research Mexican American HABLE Study Team Neurological Acquired Cognitive Impairment Genetics Biomedical Imaging Dementia 4.2 Evaluation of markers and technologies |
| Zdroj: | Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 |
| Popis: | IntroductionMexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.MethodsCommunity-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.ResultsData was examined from n=1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites.DiscussionThe current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations. |
| Databáze: | OpenAIRE |
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