Nanocomposite thin films based on titanium and zirconium dioxides for biomedical applications: electrochemical evaluation and in vitro bioactivity

Autor: García Galván, Federico, El hadad, A. A., Jiménez-Morales, A., Peón, E., Galván Sierra, Juan Carlos
Rok vydání: 2018
Předmět:
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Popis: 7th International Congress of Biomaterials
The aim of this work was to study the electrochemical corrosion behaviour and biocompatibility of Ti6Al4V biomedical alloy coated with organopolysiloxane films modified with TiO2 and ZrO2 nanoparticles. Films were prepared by sol-gel processes. Tetramethyl orthosilicate (TMOS) and 3-methacryloxypropyltrimethoxysilane (MAPTMS) were used as precursors of the organic- inorganic network. Titanium tetrabutoxide (TBT) and zirconium tetrabutoxide (ZBT) were used as precursors of dioxide nanoparticles. The thermal stability of the organic-inorganic hybrids was studied by thermogravimetric analysis (TG/DTA). The structural characterization was carried out by infrared spectroscopy (ATR-FTIR). The hydrophilicity of the coatings was determined by measurements of the contact angle. Finally, the morphology and the composition of the coatings was characterized by scanning electron microscopy and X-ray dispersive energy (SEM/EDX). The corrosion behavior of the metal/coating systems during immersion tests in Kokubo's simulated body fluid (SBF) was studied by applying global and localized electrochemical impedance spectroscopy (EIS and LEIS). The in vitro bioactivity of the coatings was evaluated after immersion tests in SBF by SEM/EDX and X-ray diffraction (XRD) analyses. The in vitro biocompatibility was evaluated by adsorption tests of proteins (fibrinogen). This study was carried out applying the Bradford method and ATR-FTIR, after immersion in fibrinogen solutions. As a summary, it can conclude that uniform, homogeneous and free of cracks nanocomposite coatings have been successfully. Electrochemical evaluation and in vitro bioactivity studies confirmed that these systems can be potentially interesting for the development of new coatings for orthopedic Ti6Al4V implants.
Databáze: OpenAIRE
Externí odkaz: