Polyunsaturated fatty acids and plasmalogens in diabetics
| Autor: | Koehrer, Philippe, Acar, Niyazi, SAAB, Sarah, Isaico, Rodica, Bron, Alain, Bretillon, Lionel, Creuzot Garcher, Catherine |
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| Přispěvatelé: | Department of Ophthalmology, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), ProdInra, Archive Ouverte |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition 583 lipids [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition 499 diabetic retinopathy [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs lipid [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs lipids (amino acids peptides and proteins) [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition lipide [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology diabète |
| Zdroj: | ARVO Annual Meeting Abstract annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO) annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO), May 2013, Seattle, Washington, United States. 1 p annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO), May 2013, Seattle, Washington, United States. Association for Research in Vision and Ophthalmology, ARVO Annual Meeting Abstract, 54, 1 p., 2013, Investigative Ophthalmology and Visual Science |
| Popis: | PurposePlasmalogens are phospholipids characterized by a vinyl ether bond and a preferential esterification of polyunsaturated fatty acids (PUFA). We have previously shown that the lack of plasmalogens leads to retinal hyper-capillarization. We hypothesize that plasmalogens are negative regulators of vascular development, and aimed to check their circulating levels in diabetic patients with a retinopathy. MethodsBlood samples were collected from 88 patients and 14 control subjects. Among diabetics we had 14 patients without diabetic retinopathy (DR), 12 with a mild non proliferative DR, 12 with a moderate non proliferative DR, 22 with a severe non proliferative DR and 24 with a proliferative DR (PDR). Erythrocytes were isolated from total blood samples. The plasmalogen content and the fatty acid composition of erythrocyte phospholipids were determined using capillary column gas chromatography. Individual species of phospholipids, including plasmalogens, were quantified by liquid chromatography coupled with a triple quadrupole mass spectrometry instrument (HPLC-ESI+MS/MS). ResultsGas chromatographic analyzes showed significant reduced levels of omega-3 PUFAs including docosahexaenoic acid (DHA) (p |
| Databáze: | OpenAIRE |
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