Zn-Catalyzed Direct Synthesis of 3-Iodo-1,3-dienes from ¿-Allenols
| Autor: | Toledano-Pinedo, M., Peñín, B., Martínez del Campo, Teresa, Almendros, Pedro |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), European Commission |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 2018-0950 |
| Popis: | In recent years, the chemistry of allenes has attracted the attention of many chemists giving rise to numerous studies due to the presence of a cumulated diene in the structure of the compound. Therefore, these allenes have allowed to prepare a variety of compounds of chemical and biological interest. On the other hand, 3-iodo-1,3-dienes are interesting species in organic chemistry because of its wide reactivity. They can undergo Diels-Alder cycloaddition, palladium-catalyzed cross-coupling reactions such as Stille, Negishi, Sonogashira and carbonylation, as well as solvolysis and metallation reactions. We wish to report herein a new protocol that allows to obtain 3-iodo-1,3-dienes through a sustainable process starting from α-allenols. In this new synthetic route, zinc (II) derivatives are used as metallic promoter which are low cost and are also non-polluting species for the environment This work was supported in part by AEI (MICIU) and FEDER (Project PGC2018-095025-B-I00) |
| Databáze: | OpenAIRE |
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