Crizotinib efficacy in alk-positive advanced stage non-small cell lung cancer patients: A real-world experience from Turkey

Autor: Kilickap, S., Ozturk, A., Karadurmus, N., Korkmaz, T., Yumuk, P., Cicin, I., Paydas, S., Cilbir, E., Sakalar, T., Uysal, M., Uskent, N., Demir, N., Sakin, A., Turhal, N., Keskin, S., Tural, D., Eralp, Y., Basal, F., Hatime Yasar, Sendur, M. A., Demirci, U., Cubukcu, E., Karaagac, M., Karaca, S., Tatli, A., Yetisyigit, T., Urvay, S., Gursoy, P., Uluc, B. Oyan, Turna, Z., Kucukoner, M., Olmez, O., Cabuk, D., Seker, M., Unal, O., Meydan, N., Okutur, S., Tunali, D.
Přispěvatelé: Kilickap, S. Hacettepe Univ, Fac Med, Dept Med Oncol, Ankara, Turkey, Ozturk, A. Istanbul Sureyyapasa Chest Dis & Thorac Surg Trai, Istanbul, Turkey, Karadurmus, N. Saglik Bilimleri Univ, Fac Med, Dept Med Oncol, Ankara, Turkey, Korkmaz, T. Acibadem Maslak Hosp, Istanbul, Turkey, Yumuk, P. Marmara Univ, Fac Med, Dept Med Oncol, Istanbul, Turkey, Cicin, I. Trakya Univ, Fac Med, Dept Med Oncol, Edirne, Turkey, Paydas, S. Cukurova Univ, Balcali Hosp, Adana, Turkey, Cilbir, E. Diskapi Yildirim Beyazit Training & Res Hosp, Ankara, Turkey, Sakalar, T. Erciyes Univ, Fac Med, Med Oncol, Kayseri, Turkey, Uysal, M. Afyon Kocatepe Univ, Fac Med, Med Oncol, Afyon, Turkey, Uskent, N., Turhal, N. Anadolu Med Ctr, Kocaeli, Turkey, Demir, N. Sivas Numune Hosp, Sivas, Turkey, Sakin, A. Okmeydani Training & Res Hosp, Istanbul, Turkey, Keskin, S. Mem Sisli Hosp, Istanbul, Turkey, Tural, D. Istanbul Bakirkoy Training & Res Hosp, Med Oncol, Istanbul, Turkey, Eralp, Y. Istanbul Univ, Inst Oncol, Istanbul, Turkey, Basal, F. Ankara Ataturk Chest Dis & Thorac Surg Training &, Ankara, Turkey, Yasar, H. Ankara Univ, Fac Med, Ankara, Turkey, Sendur, M. A. Yildirim Beyazit Univ, Fac Med, Ankara, Turkey, Demirci, U. Saglik Bilimleri Univ, Dr Abdurrahman Yurtaslan Ankara Oncol Training &, Dept Med Oncol, Ankara, Turkey, Cubukcu, E. Bursa Uludag Univ, Fac Med, Bursa, Turkey, Karaagac, M. Necmettin Erbakan Univ, Meram Fac Med, Konya, Turkey, Karaca, S. Ege Univ, Fac Med, Izmir, Turkey, Tatli, A. Akdeniz Univ, Fac Med, Antalya, Turkey, Yetisyigit, T. Namik Kemal Univ Hosp, Med Oncol, Tekirdag, Turkey, Urvay, S. Acibadem Kayseri Hosp, Kayseri, Turkey, Gursoy, P. Izmir Dr Suat Seren Thorac Dis & Surg Training &, Izmir, Turkey, Uluc, B. Oyan Acibadem Altunizade Hosp, Istanbul, Turkey, Turna, Z. Istanbul Univ, Cerrahpasa Fac Med, Istanbul, Turkey, Kucukoner, M. Dicle Univ, Fac Med, Diyarbakir, Turkey, Olmez, O. Medipol Univ Hosp, Istanbul, Turkey, Cabuk, D. Kocaeli Univ, Fac Med, Kocaeli, Turkey, Seker, M. Bayindir Hosp Sogutozu, Ankara, Turkey, Unal, O. Izmir Bozyaka Training & Res Hosp, Izmir, Turkey, Meydan, N. Adnan Menderes Univ, Fac Med, Aydin, Turkey, Okutur, S. Med Pk Bahcelievler Hosp, Istanbul, Turkey, Tunali, D. Koc Univ, Fac Med, Istanbul, Turkey
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Web of Science
Popis: WOS: 000454014501235 Background: Increasing evidence leads to a ratiocination that genetic heterogeneity of the lung adenocarcinoma patients with sensitive EGFR mutations may impact clinical responses and outcomes to EGFR-TKIs. Method: We performed targeted NGS with a gene panel covering 416 cancer-related genes to profile genetic characteristics of 69 lung adenocarcinoma patients with activating EGFR mutations and assessed the contribution of targeted NGS to exploration of genetic heterogeneity of such cohort. Result: We detected total 200 actionable genetic alterations (mean 2.9 variations per patient, range: 1-7 variations) in tumor DNA and 140 actionable genetic alterations (mean 2.0 variations per patient, range: 0-5 variations) in matched plasma ctDNA, respectively. The concurrent genes with the highest mutation rate were TP53 (observed in 72.5% patients), other uncommon EGFR mutations (observed in 21.7% patients), EGFR amplification (observed in 20.3% patients), RB1 (observed in 10.1% patients), PIK3CA (observed in 7.2% patients), and MYC (observed in 5.8% patients). NGS provides EGFR mutation detection in plasma with a test sensitivity of 88.2% and specificity of 100.0%.
Databáze: OpenAIRE
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