Perinatal antibiotic treatment of sows affects intestinal barrier and immune system in offspring
| Autor: | Ferret-Bernard, Stéphanie, Boudry, Gaëlle, Le Normand, Laurence, Rome, Véronique, Savary, Gérard, Perrier, Cécile, Lalles, Jean Paul, Luron, Isabelle |
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| Přispěvatelé: | Alimentation Adaptations Digestives, Nerveuse et Comportementales (ADNC), Institut National de la Recherche Agronomique (INRA), ProdInra, Archive Ouverte, centre de rennes-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-centre de rennes |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | 64. Annual Meeting of the European Federation of Animal Science (EAAP) 64. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2013, Nantes, France. Wageningen Academic Publishers, Annual Meeting of the European Association for Animal Production, 19, 2013, Annual Meeting of the European Association for Animal Production 64. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2013, Nantes, France. Wageningen Academic Publishers, 19, 2013, Annual Meeting of the European Association for Animal Production |
| Popis: | Maternal environment during pregnancy and lactation influences health of the offspring and its microbiota.Immune tolerance to dietary and commensal microbiota antigens develops early in life. Our aim was toinvestigate intestinal barrier and local immune response to LPS in piglets deriving from sows whosemicrobiota was manipulated by antibiotics. Long-term consequences on gut adaptation to a high fat diet wereexamined in growing offspring. Sows were given amoxicillin (AMX; 40 mg/kg/d) per os (n=11 AMX) ornot (n=12 CTL) from 10 d before to 21 d after parturition. One piglet per litter was sacrificed at post-natalday (PND) 14, 21 and after weaning at PND42. The remaining ones were given either a low fat (LF) or ahigh fat (HF) diet (to enhance LPS epithelial passage) from PND140 to 169. At PND14, ileal permeabilitywas greater in AMX than CTL piglets (P |
| Databáze: | OpenAIRE |
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