| Autor: |
Ziętak, Marika, Kovatcheva-Datchary, Petia, Markiewicz, Lidia H., Ståhlman, Marcus, Kozak, Leslie P., Bäckhed, Fredrik |
| Jazyk: |
angličtina |
| Předmět: |
|
| Zdroj: |
Cell Metabolism. (6):1216-1223 |
| ISSN: |
1550-4131 |
| DOI: |
10.1016/j.cmet.2016.05.001 |
| Popis: |
SummaryMaintenance of body temperature in cold-exposed animals requires induction of thermogenesis and management of fuel. Here, we demonstrated that reducing ambient temperature attenuated diet-induced obesity (DIO), which was associated with increased iBAT thermogenesis and a plasma bile acid profile similar to that of germ-free mice. We observed a marked shift in the microbiome composition at the phylum and family levels within 1 day of acute cold exposure and after 4 weeks at 12°C. Gut microbiota was characterized by increased levels of Adlercreutzia, Mogibacteriaceae, Ruminococcaceae, and Desulfovibrio and reduced levels of Bacilli, Erysipelotrichaceae, and the genus rc4-4. These genera have been associated with leanness and obesity, respectively. Germ-free mice fed a high-fat diet at room temperature gained less adiposity and improved glucose tolerance when transplanted with caecal microbiota of mice housed at 12°C compared to mice transplanted with microbiota from 29°C. Thus, a microbiota-liver-BAT axis may mediate protection against obesity at reduced temperature. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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