Exposure to a slightly sweet lipid-based nutrient supplement during early life does not increase the level of sweet taste most preferred among 4- to 6-year-old Ghanaian children: follow-up of a randomized controlled trial
| Autor: | Okronipa, Harriet, Arimond, Mary, Arnold, Charles D, Young, Rebecca R, Adu-Afarwuah, Seth, Tamakloe, Solace M, Ocansey, Maku E, Kumordzie, Sika M, Oaks, Brietta M, Mennella, Julie A, Dewey, Kathryn G |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Sucrose Clinical Trials and Supportive Activities Reproductive health and childbirth Ghana Medical and Health Sciences Food Preferences Engineering children Clinical Research Monell forced-choice test Humans Child Preschool Nutrition Pediatric integumentary system Nutrition & Dietetics Prevention Infant Nutrients Lipid Metabolism sweet taste preference Taste Infant Food Female lipid-based nutrient supplement Follow-Up Studies |
| Zdroj: | The American journal of clinical nutrition, vol 109, iss 4 |
| Popis: | BACKGROUND:The impact of feeding a slightly sweet nutrient supplement early in life on later sweet taste preference is unknown. OBJECTIVE:We tested the hypothesis that the level of sucrose most preferred by 4-6-y-old children exposed to a slightly sweet lipid-based nutrient supplement (LNS) early in life would not be higher than that of children never exposed to LNS. DESIGN:We followed up children born to women (n=1,320) who participated in a randomized trial in Ghana. In one group, LNS was provided to women on a daily basis during pregnancy and the first 6 mo postpartum and to their infants from age 6 to 18 mo (LNS group). The control groups received daily iron and folic acid or multiple micronutrients during pregnancy and the first 6 mo postpartum, with no infant supplementation (non-LNS group). At age 4-6 y, we randomly selected a subsample of children (n=775) to assess the concentration of sucrose most preferred using the Monell 2-series, forced-choice, paired-comparison tracking procedure. We compared LNS with non-LNS group differences using a noninferiority margin of 5% weight/volume (wt/vol). RESULTS:Of the 624 children tested, most (61%) provided reliable responses. Among all children, the mean±SD sucrose solution most preferred (% wt/vol) was 14.6±8.6 (LNS group 14.9±8.7; non-LNS group 14.2±8.4). However, among children with reliable responses, it was 17.0±10.2 (LNS group 17.5±10.4; non-LNS group 16.5±10.0). The upper level of the 95% CI of the difference between groups did not exceed the noninferiority margin in either the full sample or those with reliable responses, indicating that the LNS group did not have a higher sweet preference than the non-LNS group. CONCLUSION:Exposure to a slightly sweet nutrient supplement early in life did not increase the level of sweet taste most preferred during childhood. This trial was registered at clinicaltrials.gov as NCT00970866. |
| Databáze: | OpenAIRE |
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