Adrenomedullin is not Related to Acute Hypoxic Pulmonary Vascular Response in Patients with Chronic Respiratory Disease
| Autor: | Furukawa, Katsuyuki, Ikeda, Satoshi, Iwasaki, Tadasu, Matsushita, Tetsuro, Yakabe, Kazuaki, Yamaguchi, Kenji, Miyahara, Yoshiyuki, Kohno, Shigeru |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Acta medica Nagasakiensia. 44(3-4):55-60 |
| ISSN: | 0001-6055 |
| Popis: | In the present study, acute hypoxia was induced in 19 patients with chronic respiratory disease to evaluate the corre lation between pulmonary circulation kinetics and adrenomedullin (AM) levels. Using radioimmunoassay (RIA), pulmonary circulation kinetics were evaluated before and after hypoxic loading (13% oxygen for 15 minutes) by determining AM levels in plasma obtained from the pulmonary artery (PA) and the right femoral artery (FA). There were no significant differences in pre-hypoxia plasma AM levels between samples obtained from the PA and FA, and plasma AM levels did not change after hypoxic loading. Subjects were classified into two groups [responders (R) and non-responders (NR) ] to evaluate changes in the mean pulmonary arterial pressure(笆ｳMPAP). There were no changes in AM levels between these two groups in either the PA or FA after hypoxic loading. These results suggest that AM do not appear to be related to hypoxic pulmonary vascular response to acute hypoxic loading in patients with chronic respiratory disease. Acta medica Nagasakiensia. 1999, 44(3-4), p.55-60 |
| Databáze: | OpenAIRE |
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