Tumor Microenvironment and Immune Effects of Antineoplastic Therapy in Lymphoproliferative Syndromes
| Autor: | Alvaro, Tomás, Cruz-Merino, Luis de la, Henao-Carrasco, Fernando, Villar Rodríguez, José Luis, Vicente Baz, David, Codes Manuel de Villena, Manuel, Provencio, Mariano |
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| Přispěvatelé: | [Álvaro,T] Pathology Department, Hospital de Tortosa, Verge de la Cinta, Tortosa, Spain. [Cruz-Merino,L de la, Henao-Carrasco,F, Vicente Baz,D, Codes Manuel de Villena,M] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Villar Rodríguez,JL] Pathology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Provencio,M] Clinical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Trastornos linfoproliferativos Article Subject Microambiente tumoral Animales Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [Medical Subject Headings] Organisms::Eukaryota::Animals [Medical Subject Headings] Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment [Medical Subject Headings] Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders [Medical Subject Headings] Antineoplásicos Humanos |
| Zdroj: | Journal of Biomedicine and Biotechnology. |
| ISSN: | 1110-7243 |
| DOI: | 10.1155/2010/846872 |
| Popis: | Journal Article; Review; Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future. Yes |
| Databáze: | OpenAIRE |
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