Guidelines for the welfare and use of animals in cancer research

Autor: Workman, P, Aboagye, EO, Balkwill, F, Balmain, A, Bruder, G, Chaplin, DJ, Double, JA, Everitt, J, Farningham, DAH, Glennie, MJ, Kelland, LR, Robinson, V, Stratford, IJ, Tozer, GM, Watson, S, Wedge, SR, Eccles, SA, Committee of the National Cancer Research Institute
Rok vydání: 2010
Předmět:
Male
Biomedical Research
replacement
radiation therapy
drugs
Mice
Neoplasms
genetically engineered mouse models
pharmocokinetic
Aetiology
tumour burden
Cancer
imaging
anaesthesia
fundamental and translational research
humane endpoints
Treatment Outcome
publication
restraint
Practice Guidelines as Topic
Public Health and Health Services
Female
Development of treatments and therapeutic interventions
Algorithms
Diagnostic Imaging
Animal Experimentation
tumour models
best practice
Oncology and Carcinogenesis
metastatic models
Animal Welfare
pharmacodynamic and efficacy studies
Cell Line
human tumour xenografts
Animals
Humans
Oncology & Carcinogenesis
therapy
Animal
Disputed aetiology and other
Pharmacological
Committee of the National Cancer Research Institute
orthotopic models
Xenograft Model Antitumor Assays
5.9 Resources and infrastructure (treatment development)
imaging techniques
Transformed
Disease Models
cancer research
reduction and refinement
clinical signs
2.6 Resources and infrastructure (aetiology)
Neoplasm Transplantation
Biomarkers
pilot studies
Zdroj: British journal of cancer, vol 102, iss 11
Popis: Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.
Databáze: OpenAIRE
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