| Autor: |
Jia-Yan Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Hainan Medical University, Vol 24, Iss 04, Pp 1-4 (2018) |
| ISSN: |
1007-1237 |
| Popis: |
Objective: To investigate the metastin expression in the placenta tissue of preeclampsia and its effect on the trophoblast cell proliferation and apoptosis. Methods: A total of 80 puerperae with preeclampsia who gave birth in this hospital between September 2014 and December 2016 were collected as observation group and 50 normal puerperae who gave birth in the hospital during the same period were collected as normal control group. The metastin protein expression as well as the trophoblast cell proliferation and apoptosis gene expression in placenta tissue were compared between the two groups of puerperae, and Pearson test was used to evaluate the metastin expression in the placenta tissue of preeclampsia and its effect on the trophoblast cell proliferation and apoptosis. Results: Metastin protein expression in the placenta tissue of observation group was significantly higher than that of normal control group. Trophoblast cell proliferation genes Notch1 and HLA-G mRNA expression in the placenta tissue of observation group were lower than those of normal control group whereas PHLDA2 mRNA expression was higher than that of normal control group; apoptosis genes bcl-2 mRNA expression was lower than that of control group whereas bax, Fas and caspase-3 mRNA expression were higher than those of normal control group. Pearson test showed that metastin protein expression in the placenta tissue of puerperae with preeclampsia was directly correlated with the trophoblast cell proliferation and apoptosis gene expression. Conclusion: There is abnormally high metastin protein expression in placenta tissue of puerperae with preeclampsia, and it can directly affect the proliferation and apoptosis process of trophoblast cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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