Scientific Reports
| Autor: | Costa, Maria Fernanda Furtado de Lima e, Rodrigues, Laura C., Barreto, Mauricio Lima, Gouveia, Mateus, Horta, Bernardo Lessa, Mambrini, Juliana |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| Popis: | Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2016-05-09T19:14:41Z No. of bitstreams: 1 Art Per Estrang Mauricio Barreto6. 2015.pdf: 480911 bytes, checksum: 8e232f4f7687590d9becac30d1cb744d (MD5) Made available in DSpace on 2016-05-09T19:14:41Z (GMT). No. of bitstreams: 1 Art Per Estrang Mauricio Barreto6. 2015.pdf: 480911 bytes, checksum: 8e232f4f7687590d9becac30d1cb744d (MD5) Previous issue date: 2015 Brazil never had segregation laws defining membership of an ethnoracial group. Thus, the composition of the Brazilian population is mixed, and its ethnoracial classification is complex. Previous studies showed conflicting results on the correlation between genome ancestry and ethnoracial classification in Brazilians. We used 370,539 Single Nucleotide Polymorphisms to quantify this correlation in 5,851 community-dwelling individuals in the South (Pelotas), Southeast (Bambui) and Northeast (Salvador)Brazil. European ancestry was predominant in Pelotas and Bambui (median5 85.3% and 83.8%,respectively). African ancestry was highest in Salvador (median 5 50.5%). The strength of the association between the phenotype and median proportion of African ancestry varied largely across populations, with pseudo R2 values of 0.50 in Pelotas, 0.22 in Bambui and 0.13 in Salvador. The continuous proportion of African genomic ancestry showed a significant S-shape positive association with self-reported Blacks in the three sites, and the reverse trend was found for self reported Whites, with most consistent classifications in the extremes of the high and low proportion of African ancestry. In self-classified Mixed individuals, the predicted probability of having African ancestry was bell-shaped. Our results support the view that ethnoracial self-classification is affected by both genome ancestry and non-biological factors. London |
| Databáze: | OpenAIRE |
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