Antitumoral activity of micellar solutions containing allyl isothiocyanate: an in vitro study
| Autor: | Cunha Almeida,Tamires, Teixeira de Oliveira,Daiane, Ventura Sávio,André Luiz, Barçante Perasoli,Fernanda, Nicioli da Silva,Glenda, Barichello,Jose Mário |
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| Přispěvatelé: | Univ Fed Ouro Preto, Universidade Estadual Paulista (Unesp), Univ Fed Pelotas |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Ars Pharmaceutica, Vol 62, Iss 1, Pp 40-51 (2021) Ars Pharmaceutica (Internet) v.62 n.1 2021 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP SciELO España: Revistas Científicas Españolas de Ciencias de la Salud Instituto de Salud Carlos III (ISCIII) |
| ISSN: | 2340-9894 |
| Popis: | Made available in DSpace on 2021-06-25T11:48:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Introduction: Several natural products exhibit promising antineoplastic activity against bladder cancer cells, including allyl isothiocyanate (AITC). However, the AITC irritates the mucous membranes and induces eczematous or vesicular skin reactions. Thus, pharmaceutical formulations are necessary to overcome these problems. The aim was to develop micellar solutions containing AITC and investigate their antitumoral activity in bladder carcinoma cell lines. Method: The micellar solutions were prepared by cold dispersion method. Subsequently, we evaluated cytotoxicity, cell proliferation, cell cycle kinetics and long-term effects of micelles in bladder cancer cells. Results: Cytotoxicity and cell proliferation assays showed there was an increase in AITC activity when it was encapsulated in micelles. We also observed cell cycle arrest in the S phase after treatment with AITC-micelles. Furthermore, the formulation was able to maintain the long-term effects of free AITC. Conclusions: The micellar solutions developed can become an interesting approach for administration of AITC in the treatment of bladder cancer. Univ Fed Ouro Preto, Lab Pesquisas Clin, Ouro Preto, Brazil Univ Fed Ouro Preto, Lab Bioquim & Biol Mol, Ouro Preto, Brazil Univ Estadual Paulista, Lab Toxicogen & Nutrigen, Botucatu, SP, Brazil Univ Fed Ouro Preto, Lab Fitotecnol, Ouro Preto, Brazil Univ Fed Pelotas, Lab Tecnol Farmaceut, Pelotas, RS, Brazil Univ Estadual Paulista, Lab Toxicogen & Nutrigen, Botucatu, SP, Brazil FAPEMIG: PPM-00282-11 FAPEMIG: CBB-APQ-01497-14 |
| Databáze: | OpenAIRE |
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