PopAffiliator: online calculator for individual affiliation to a major population group based on 17 autosomal STR genotype profile

Autor: Pereira, L, Alshamali, F, Andreassen, R, Ballard, R, Chantratita, W, Cho, NS, Coudray, C, Dugoujon, JM, Espinoza, M, González-Andrade, F, Hadi, S, Immel, U-D, Marian, C, Gonzalez-Martin, A, Mertens, G, Parson, W, Perone, C, Prieto, L, Takeshita, H, Villalobos, HR, Zeng, Z, Zhivotovsky, L, Camacho, R, Fonseca, NA
Přispěvatelé: Instituto de Investigação e Inovação em Saúde
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Popis: Because of their sensitivity and high level of discrimination, short tandem repeat (STR) maker systems are currently the method of choice in routine forensic casework and data banking, usually in multiplexes up to 15-17 loci. Constraints related to sample amount and quality, frequently encountered in forensic casework, will not allow to change this picture in the near future, notwithstanding the technological developments. In this study, we present a free online calculator named PopAffiliator ( http://cracs.fc.up.pt/popaffiliator ) for individual population affiliation in the three main population groups, Eurasian, East Asian and sub-Saharan African, based on genotype profiles for the common set of STRs used in forensics. This calculator performs affiliation based on a model constructed using machine learning techniques. The model was constructed using a data set of approximately fifteen thousand individuals collected for this work. The accuracy of individual population affiliation is approximately 86%, showing that the common set of STRs routinely used in forensics provide a considerable amount of information for population assignment, in addition to being excellent for individual identification. IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science, Technology and Higher Education and is partially supported by FCT, the Portuguese Foundation for Science and Technology. CRACS-INESC Porto is supported by Programa Operacional Ciência, Tecnologia e Inovação (POCTI) e Quadro Comunitário de Apoio III. NJ and DH were supported by grant 196-1962766-2751. LZh received grants from the Russian Academy of Science for Mol & Cell Biol and FSM.
Databáze: OpenAIRE
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