Analysis of Hemodynamic Changes and Bold Signals of Sickle Cell Disease Patients during Desaturation
| Autor: | Coloigner, Julie, Vu, Chau, Borzage, Matt, Bush, Adam, Lepore, Natasha, Coates, Thomas D., Wood, John |
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| Přispěvatelé: | Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Children’s Hospital Los Angeles [Los Angeles], Department of Cardiology, Childrens Hospital Los Angeles, University of Southern California (USC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Coloigner, Julie |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | 57th American Society of Hematology (ASH) conference 57th American Society of Hematology (ASH) conference, 2015, Orlando, United States |
| Popis: | International audience; Using nearinfrared spectroscopy (NIRS), previous studies have shown that sicklecell disease (SCD) patients have low cerebral oxygen saturation values. Moreover, the hemoglobin S in sickle cell disease has impaired oxygen carrying capacity. Here, we propose to investigate the effect of induced desaturation on the SCD brain. In particular, we analyzed the falling functional magnetic resonance imaging (fMRI) response during hypoxia, which results from local concentration changes in paramagnetic deoxyhemoglobin (DHB). Moreover, we also explore the nearinfrared spectroscopy (NIRS) changes in oxygenated and deoxygenated hemoglobin from the human prefrontal cortex. |
| Databáze: | OpenAIRE |
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