Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test
| Autor: | Hatip-Al-Khatib I, Egashira N, Mishima K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
arginine error choice animal behavior Paeonia butanol Toki-Shakuyaku-San Cognition medicinal plant n methyl beta carboline 3 carboxamide rat Angelica Cnidium rhizome article Atractylodes lancea memory disorder spatial memory unclassified drug amine Alisma orientale extract herbal medicine plant extract Alisma hexanol Angelica root Scopolamine animal experiment Paeonia radix Spatial Behavior Animals Cognition/*drug effects/physiology Dose-Response Relationship Drug Drugs Chinese Herbal/isolation & purification/pharmacology/*therapeutic use Maze Learning/*drug effects/physiology Memory Disorders/chemically induced/*drug therapy Plant Extracts/isolation & purification/pharmacology/therapeutic use Rats Rats Wistar Scopolamine/*toxicity Spatial Behavior/drug effects/radiation effects Cnidium working memory Paeonia lactiflora poria cocos choline cnidium officinale monosaccharide correct choice tokishakuyaku san chemical composition tryptophan controlled study maze test Alisma orientale Maze Learning methanol eight armed radial maze test Memory Disorders lysine nonhuman Plant Extracts animal model angelica acutiloba Atractylodes Atractylodes extract alkaloid Angelica acutiloba extract drug efficacy herbaceous agent polysaccharide adolescent Poria cocos extract dialysis N-methyl-β-carboline-3- carboxamide disaccharide Drugs Chinese Herbal |
| Popis: | The improving effects of various components of Toki-Shakuyaku-San (TSS) and fractions isolated from Angelica acutiloba Radix (Toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. The scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. Toki, Cnidium officinale Rhizoma (Senkyu), Poria cocos Hoelen (Bukuryo), Alisma orientale Rhizoma (Takusha), and Atractylodes lancea Rhizoma (Sojutsu) increased the correct choices, while only the Toki, Sojutsu, and Takusha decreased the error choices. No effect was produced by Paeonia lactiflora Radix (Shakuyaku). Investigation of effects of fractions isolated from Toki revealed that its activity mainly resided in the butanol layer and its contents of N-methyl-beta-carboline-3-carboxamide and amines. Moreover, the alkaloid, internal and external solutions (containing poly-, di-, and monosaccharides) obtained by dialysis with Visking cellophane tubing also improved the memory. However, no improving properties were detected for methanol and hexanol layers, L-(-)-tryptophan, L-arginine, L-(-)-lysine, and choline chloride. The results showed that the TSS components could improve the reference and working memory impaired by scopolamine. The improving effect of TSS is produced greatly by the Toki component, the activity of which was greatly produced by the fraction extracted by butanol. |
| Databáze: | OpenAIRE |
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