CLINICAL CHARACTERISTICS, POST-TREATMENT ASSESSMENT AND PROGNOSTIC FACTORS AFFECTING PATIENT SURVIVAL OF PATIENTS AT 65 YEARS OF AGE OR OLDER WITH HODGKIN LYMPHOMA: A RETROSPECTIVE MULTICENTER STUDY FROM TURKEY
| Autor: | Ilhami BERBER, Erkurt, Mehmet Ali, Keklik, Muzaffer, Dogu, Mehmet Hilmi, Terzi, Hatice, Pala, Cigdem, Sari, Hakan Ismail, Sencan, Mehmet, Sivgin, Serdar, Hacioglu, Sibel, Altuntas, Fevzi, Aydogdu, Ismet, Ilhan, Osman |
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| Přispěvatelé: | [Berber, Ilhami -- Erkurt, Mehmet Ali] Inonu Univ, Hematol, TR-44069 Malatya, Turkey -- [Keklik, Muzaffer -- Pala, Cigdem -- Sivgin, Serdar] Erciyes Univ, Hematol, Kayseri, Turkey -- [Dogu, Mehmet Hilmi -- Sari, Hakan Ismail -- Hacioglu, Sibel] Pamukkale Univ, Hematol, Denizli, Turkey -- [Terzi, Hatice -- Sencan, Mehmet] Cumhuriyet Univ, Hematol, Sivas, Turkey -- [Altuntas, Fevzi] Celal Bayar Univ, Ankara Oncol Hosp, Yildirim Beyazit Univ, Hematol, Manisa, Turkey -- [Aydogdu, Ismet] Celal Bayar Univ, Fac Med, Dept Hematol, Manisa, Turkey -- [Ilhan, Osman] Ankara Univ, Ibni Sina Hosp, Hematol, TR-06100 Ankara, Turkey, keklik, muzaffer -- 0000-0002-6426-5249, Altuntas, Fevzi -- 0000-0001-6872-3780 |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
cancer patient
drug megadose autologous stem cell transplantation Hodgkin disease chlormethine overall survival retrospective study cisplatin dacarbazine dexamethasone elderly patients doxorubicin etoposide vincristine Article Turkey (republic) multiple cycle treatment post treatment survival fatality immune system diseases cytarabine hemic and lymphatic diseases vinblastine human cancer survival lymphocyte-rich classical Hodgkin lymphoma procarbazine clinical article progression free survival bleomycin sedimentation rate ifosfamide ferritin aging prognostic factors clinical feature nodular lymphocyte predominant Hodgkin lymphoma aged comorbidity carboplatin prednisone multicenter study (topic) treatment outcome prognosis protein Hodgkin lymphoma |
| Zdroj: | Scopus-Elsevier Web of Science |
| Popis: | WOS: 000375337000011 Introduction: During the last three decades, major advances have been made in the therapy of Hodgkin's lymphoma. However, despite these advances, Hodgkin's lymphoma has a poor prognosis in the elderly. The proportion of Hodgkin's lymphoma patients aged > 60 ranges in the different reports between 15% and 35%. This study aimed to examine clinical characteristics, treatment outcomes and prognostic factors affecting patient survival in Hodgkin's lymphoma patients aged 65 years or older. Material methods: Hodgkin's lymphoma patients at 65 years of age and older managed within last 5 years in a total of 5 centers in Turkey were retrospectively assessed. Results: The median age of a total of 32 patients was 71 (65-83) years. Elderly patients presented more frequently with B symptoms, elevated sedimentation rate, mixed cellularity histologic subtype and comorbid disease. Less frequent were bulky disease, bone marrow involvement, and the application of autologous stem cell transplantation. The nodular lymphocyte predominant subtype and lymphocyte rich subtype were not observed at all. Eastern Cooperative Oncology Group, ferritin, total protein, and histological type were significant predictors affecting survival (p |
| Databáze: | OpenAIRE |
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